Ultrasound Imaging As A Visualization Aid During Intravaginal Ring Drug Development
ePoster
Authors: Amani Patterson, UTMB Melody Paul, UTMB Lauren Dawson, University of Texas Medical Branch John Moss, Oak Crest Institute of Science Marc Baum, Oak Crest Institute of Science Kathleen L. Vincent, UTMB ,
Ultrasound can be implemented in localizing intravaginal ring (IVR) devices and accurately visualizing their relation to female pelvic structures. Two studies enrolled 10 and 12 women to use IVRs. The device's location was evaluated by digital, speculum, and ultrasound examination. Distances from the superficial edge of the IVR to the pubic symphysis and vaginal introitus were measured from transabdominal and transperineal 2D/3D ultrasound images. From these images, anatomic diagrams were created from sagittal views to provide visual context between the IVR and female pelvic structures to scale. These studies showed no evidence of IVR movement, expulsion, irritation, or deformity in situ or after activity. The deep edge of the IVR was located either anterior, inferior, or posterior to the cervix depending on a participant’s anatomy. Investigations of this nature can provide foundational information needed for further studies, optimize device development for drug delivery, and enhance continued education for providers. Additionally, they can help create more realistic expectations of IVR usage for patients, regarding insertion and removal, and potentially increasing adherence to this method for drug delivery.