Basic Science and Instrumentation Scientific Session 2
Catheter-Free Pressure Measurements in Human Bladder With Subharmonic-Aided Pressure Estimation (SHAPE): A proof of Concept
Sunday, April 7, 2024
2:15pm – 2:27pm
Location: 410
Authors: Kourosh Kalayeh, University of Michigan J. Brian Fowlkes, University of Michigan John DeLancey, University of Michigan James Ashton-Miller, University of Michigan William Schultz, University of Michigan Bryan Sack, Michigan Medicine ,
Urodynamic tests, the gold standard for measuring bladder pressures, require indwelling urethral catheters that can result in non-physiological measurements and potential misdiagnosis. Our study assessed SubharmonicAided Pressure Estimation (SHAPE) as a potential non-invasive alternative for these measurements, thereby enhancing patient comfort and diagnostic accuracy. Utilizing an FDA-approved contrast agent, Lumason, and specialized ultrasound scanning techniques, we have successfully applied SHAPE in a clinical setting with adult female volunteers. Our data reveals an inverse linear relationship between SHAPE signal and changes in bladder pressure, with high correlation coefficients demonstrating its reliability. Our findings have the potential to lead to a new approach in urological diagnostics that eliminates the need for catheters during voiding, paving the way for more comfortable and accurate bladder assessments.