Basic Science and Instrumentation Scientific Session 3
Measurement of Cerebral Metabolism under Non-Chronic Hemodynamic Conditions
Tuesday, April 9, 2024
5:20pm – 5:32pm
Location: 412
Authors: Oliver Kripfgans, University of Michigan Stephen Pinter, University of Michigan Brendan McCracken, University of Michigan Carmen Colmenero Mahmood, University of Michigan - Ann Arbor Venkatakrishna Rajajee, University of Michigan, Ann Arbor Mohamad Tiba, University of Michigan Jonathan Rubin, University of Michigan
Have you ever filled up your car at the gas station and paid based on the velocity of the gas or its pressure entering your tank? If gas delivery was measured using tools of present-day medicine, you would have. Your annual physical exam likely includes your blood pressure. Maybe even a pulse-wave ultrasound of your carotid as well, yielding the blood velocity in your carotid, rather than the actual volumetric blood flow. While MRI, CT, invasive catheters, and potentially other ways exist to obtain flow, they are rarely used, due to availability, time, and cost. Ultrasound is often available, cheap, and fast, but can currently not reliably obtain flow, due to several unmet assumptions, such as knowledge of flow profile and flow angle. In the present study we have furthered our previously introduced method of 3D color flow assessment of blood flow which does not require the above assumptions and has been shown to provide repeatable and accurate flow in milliliters per second. Here we investigated flow measurements under simulated injury conditions for traumatic brain injury and severe abdominal hemorrhagic blood loss. On average 3D color flow estimated flow with a bias of -9.6% relative to an invasive flow meter.