General and Abdominal Scientific and Case Reports Session 1
Initial evaluation of ultrasound-guided attenuation parameter imaging and quality assurance in phantoms and volunteers
Tuesday, April 9, 2024
11:26am – 11:33am
Location: 410
Authors: Zaiyang Long, Mayo Clinic Jaydev Dave, Mayo Clinic Nicholas Hangiandreou, Mayo Clinic Donald Tradup, Mayo Clinic Rochester MN Kevin Brom, Mayo Clinic Dawn Boynton, Mayo Clinic Kate Knoll, Mayo Clinic Anil Kurup, Mayo Clinic
There is a strong clinical need for quantification of liver parenchyma acoustic properties as early biomarkers for liver diseases. Initial evaluation of ultrasound-guided attenuation parameter imaging (UGAP) as a biomarker for liver steatosis demonstrated successful measurements in a multi-purpose quality assurance phantom by four operators, with excellent operator agreement and satisfactory repeatability coefficients and reproducibility coefficients (ranged between 0.04 and 0.11 dB/cm/MHz depending on the phantom property). In volunteers, median attenuation coefficients were between 0.57 and 0.68 dB/cm/MHz, with good operator agreement and a repeatability coefficient of 0.09 dB/cm/MHz. Further study will be performed to evaluate the accuracy and repeatability of UGAP in patients and risk stratification thresholds for steatosis grades to facilitate clinical adoption of this technology.