An in vitro investigation of Lumason’s subharmonic response for pressure estimation with direct comparison to Sonazoid and Definity
Monday, April 8, 2024
11:03am – 11:13am
Location: 406
Authors: Hailee Mayer, Thomas Jefferson University Flemming Forsberg, Thomas Jefferson University Ga Won Kim, Thomas Jefferson University Priscilla Machado, Thomas Jefferson University John Eisenbrey, Thomas Jefferson University Trang Vu, Thomas Jefferson University Hospital Kirk Wallace, GE HealthCare Technology and Innovation Center
The subharmonic response of ultrasound contrast agents (UCAs) to hydrostatic pressures can be exploited for non-invasive estimates of pressures within the body. For most commercially available UCAs, like Sonazoid (GE HealthCare, Oslo, Norway) and Definity (Lantheus Imaging, N Billerica, MA USA) there is a well-established inverse linear trend between subharmonic signal and hydrostatic pressure. However, the UCA, Lumason (Bracco, Millan, Italy, challenges the idea of the inverse linear trend. To date, groups have observed linear, inverse linear, bi-phasic, and tri-phasic trends for Lumason. Thus, this study investigated Lumason’s subharmonic response in vitro, and directly compared it to Sonazoid and Definity.