Shear Wave Elastography: A Potential Biomarker of Spinal-Bulbar & Muscular Atrophy (SBMA)
Monday, April 8, 2024
3:04pm - 3:11pm
Location: 410
Authors: Yonathan Assefa, National Institutes of Health Euan Forrest, National Institutes of Health Abdullah AlQahtani, NIH Joseph Shrader, DHHS, NIH, Clinical Center, RMD, PT Henry Roberts, National Institutes of Health / Clinical Trials Unit Katharine Alter, Clinical Center, NIH Galen Joe, National Institutes of Health Mina Jain, National Institutes of Health / Clinical Trials Unit Christopher Christopher Grunseich, NINDS, National Institutes of Health ,
In this pilot study, we set out to explore how ultrasound technology could possibly serve as a way to help develop therapies for Spinal and Bulbar Muscular Atrophy (SBMA), a dehabilitating neuromuscular disorder. We did this by exploring the untapped potential of Shear Wave Elastography (SWE) as a novel biomarker. Our findings offer a fresh perspective into the challenge of developing a reliable, sensitive marker for SBMA.
This presentation will captivate attendees with unique insights, showcasing challenges and possibilities of SWE as a diagnostic tool. We will explore the confounding factors that affected our results, emphasizing the need for larger sample sizes and further exploration. As a critical stepping stone in the search for SBMA biomarkers, our work opens up exciting avenues for the expanding role of Shear Wave Elastography in the clinical assessment of musculoskeletal disorders.
Yonathan Assefa, BS (he/him/his)
Post-Baccalaureate IRTA Fellow National Institutes of Health